Prevalence of Inflammatory Bowel Disease Among Patients with Autism Spectrum Disorders.
نویسندگان
چکیده
BACKGROUND The objective of this study was to measure the prevalence of inflammatory bowel disease (IBD) among patients with autism spectrum disorders (ASD), which has not been well described previously. METHODS The rates of IBD among patients with and without ASD were measured in 4 study populations with distinct modes of ascertainment: a health care benefits company, 2 pediatric tertiary care centers, and a national ASD repository. The rates of IBD (established through International Classification of Diseases, Ninth Revision, Clinical Modification [ICD-9-CM] codes) were compared with respective controls and combined using a Stouffer meta-analysis. Clinical charts were also reviewed for IBD among patients with ICD-9-CM codes for both IBD and ASD at one of the pediatric tertiary care centers. This expert-verified rate was compared with the rate in the repository study population (where IBD diagnoses were established by expert review) and in nationally reported rates for pediatric IBD. RESULTS In all of case-control study populations, the rates of IBD-related ICD-9-CM codes for patients with ASD were significantly higher than that of their respective controls (Stouffer meta-analysis, P < 0.001). Expert-verified rates of IBD among patients with ASD were 7 of 2728 patients in one study population and 16 of 7201 in a second study population. The age-adjusted prevalence of IBD among patients with ASD was higher than their respective controls and nationally reported rates of pediatric IBD. CONCLUSIONS Across each population with different kinds of ascertainment, there was a consistent and statistically significant increased prevalance of IBD in patients with ASD than their respective controls and nationally reported rates for pediatric IBD.
منابع مشابه
Comparison of Coping Strategies in People with Inflammatory Bowel Disease and Healthy People in Terms of Health Locus of Control
Background: Inflammatory bowel disease (IBD) is a group of disorders that cause chronic inflammation (pain and swelling) in the intestines. IBD includes Crohn’s disease and ulcerative colitis. Both types affect the digestive system. The study aims to compare coping strategies in people with inflammatory bowel disease and healthy people, according to internal and external sources of health contr...
متن کاملThe Co-Morbidity Burden of Children and Young Adults with Autism Spectrum Disorders
OBJECTIVES Use electronic health records Autism Spectrum Disorder (ASD) to assess the comorbidity burden of ASD in children and young adults. STUDY DESIGN A retrospective prevalence study was performed using a distributed query system across three general hospitals and one pediatric hospital. Over 14,000 individuals under age 35 with ASD were characterized by their co-morbidities and converse...
متن کاملAutism spectrum disorders in children of parents with inflammatory bowel disease – a nationwide cohort study in Denmark
PURPOSE Inflammatory bowel disease (IBD) and autism spectrum disorders (ASD) may share genetic and environmental risk factors. We examined whether parental IBD is associated with an increased risk of ASD in offspring. METHODS We conducted a registry-based nationwide cohort study including children born alive in Denmark from January 1, 1994 to December 31, 2009, with follow-up throughout 2010....
متن کاملمعرفی یک مورد بیماری کرون
The term “inflammatory” bowel disease” applies to idiopathic, chronic inflammatory bowel disease (IBD): Crohn’s disease and ulcerative colitis. They occur among all age groups but a peak incidence in the second and third decades. Most of IBD occur as ulcerative colitis, but the incidence of Crohn’s disease has risen over the past 20 years. These disorder ar...
متن کاملThe Effectiveness of Holistic Multi-dimensional Treatment Model (HMTM) in the Treatment of Children with Autism Spectrum Disorder (ASD)
Introduction: Autism spectrum disorders (ASD) belong to the pervasive neurodevelopmental disorders. The prevalence of ASD has increased significantly throughout recent decades, bringing the overall estimated prevalence to 11.3 per 1000 children. ASD is characterized by severe difficulties in reciprocal social interaction, stereotyped patterns of behavior and profound impairments in verbal and n...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Inflammatory bowel diseases
دوره 21 10 شماره
صفحات -
تاریخ انتشار 2015